Synergistic anticancer effect of cisplatin and Chal-24 combination through IAP and c-FLIPL degradation, Ripoptosome formation and autophagy-mediated apoptosis

Synergistic anticancer effect of cisplatin and Chal-24 combination through IAP and c-FLIPL degradation, Ripoptosome formation and autophagy-mediated apoptosis

Drug resistance is a major hurdle in anticancer chemotherapy. Combined therapy using drugs with distinct mechanisms of function may increase anticancer efficacy. We have recently identified the novel chalcone derivative, chalcone-24 (Chal-24), as a potential therapeutic that kills cancer cells throu...

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Bibliographic Details
Main Authors: Shi, Shaoqing, Wang, Qiong, Xu, Jennings, Jang, Jun-Ho, Padilla, Mabel T., Nyunoya, Toru, Xing, Chengguo, Zhang, Lin, Lin, Yong
Format: Online
Language:English
Published: Impact Journals LLC 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4359321/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4359321/

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