Metformin and trametinib have synergistic effects on cell viability and tumor growth in NRAS mutant cancer

Metformin and trametinib have synergistic effects on cell viability and tumor growth in NRAS mutant cancer

Attempts to directly block the mutant neuroblastoma rat sarcoma oncogene (NRAS) protein, a driving mutation in many cancer types, have been unsuccessful. Current treatments focus on inhibition of different components of NRAS' two main downstream cascades: PI3K/AKT/mTOR and MAPK. Here we test a...

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Bibliographic Details
Main Authors: Vujic, Igor, Sanlorenzo, Martina, Posch, Christian, Esteve-Puig, Rosaura, Yen, Adam J., Kwong, Andrew, Tsumura, Aaron, Murphy, Ryan, Rappersberger, Klemens, Ortiz-Urda, Susana
Format: Online
Language:English
Published: Impact Journals LLC 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4359268/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4359268/

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