TWIST1 and TWIST2 promoter methylation and protein expression in tumor stroma influence the epithelial-mesenchymal transition-like tumor budding phenotype in colorectal cancer

TWIST1 and TWIST2 promoter methylation and protein expression in tumor stroma influence the epithelial-mesenchymal transition-like tumor budding phenotype in colorectal cancer

Tumor budding in colorectal cancer is likened to an epithelial-mesenchymal transition (EMT) characterized predominantly by loss of E-cadherin and up-regulation of E-cadherin repressors like TWIST1 and TWIST2. Here we investigate a possible epigenetic link between TWIST proteins and the tumor budding...

Full description

Bibliographic Details
Main Authors: Galván, José A., Helbling, Melina, Koelzer, Viktor H., Tschan, Mario P., Berger, Martin D., Hädrich, Marion, Schnüriger, Beat, Karamitopoulou, Eva, Dawson, Heather, Inderbitzin, Daniel, Lugli, Alessandro, Zlobec, Inti
Format: Online
Language:English
Published: Impact Journals LLC 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4359262/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4359262/

Similar Items