SKP2 inactivation suppresses prostate tumorigenesis by mediating JARID1B ubiquitination

SKP2 inactivation suppresses prostate tumorigenesis by mediating JARID1B ubiquitination

Aberrant elevation of JARID1B and histone H3 lysine 4 trimethylation (H3K4me3) is frequently observed in many diseases including prostate cancer (PCa), yet the mechanisms on the regulation of JARID1B and H3K4me3 through epigenetic alterations still remain poorly understood. Here we report that Skp2...

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Bibliographic Details
Main Authors: Lu, Wenfu, Liu, Shenji, Li, Bo, Xie, Yingqiu, Adhiambo, Christine, Yang, Qing, Ballard, Billy R., Nakayama, Keiichi I., Matusik, Robert J., Chen, Zhenbang
Format: Online
Language:English
Published: Impact Journals LLC 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4359254/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4359254/

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