miR-26a and miR-214 down-regulate expression of the PTEN gene in chronic lymphocytic leukemia, but not PTEN mutation or promoter methylation

miR-26a and miR-214 down-regulate expression of the PTEN gene in chronic lymphocytic leukemia, but not PTEN mutation or promoter methylation

We previous found the expression level of PTEN was low in the chronic lymphocytic leukemia (CLL) patients. To assess the pathogenic contribution of the low expression of PTEN, we determined PTEN-regulating miRNA interference, PTEN promoter methylation and PTEN gene mutation condition in CLL.

Bibliographic Details
Main Authors: Zou, Zhi-Jian, Fan, Lei, Wang, Li, Xu, Ji, Zhang, Run, Tian, Tian, Li, Jian-Yong, Xu, Wei
Format: Online
Language:English
Published: Impact Journals LLC 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4359232/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4359232/

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