Dendritic and axonal mechanisms of Ca2+ elevation impair BDNF transport in Aβ oligomer–treated hippocampal neurons
Intracellular Ca2+ dysregulation and transport disruption precede cell death in Alzheimer's disease. Mechanisms of AβO-induced Ca2+ elevation are identified that regulate the onset, severity, and spatiotemporal progression of BDNF transport defects. The results challenge dogmatic views on mecha...
| Main Authors: | , |
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| Format: | Online |
| Language: | English |
| Published: |
The American Society for Cell Biology
2015
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4357506/ |