PERK silence inhibits glioma cell growth under low glucose stress by blockage of p-AKT and subsequent HK2's mitochondria translocation

PERK silence inhibits glioma cell growth under low glucose stress by blockage of p-AKT and subsequent HK2's mitochondria translocation

Glioma relies on glycolysis to obtain energy and sustain its survival under low glucose microenvironment in vivo. The mechanisms on glioma cell glycolysis regulation are still unclear. Signaling mediated by Double-stranded RNA-activated protein kinase (PKR) – like ER kinase (PERK) is one of the impo...

Full description

Bibliographic Details
Main Authors: Hou, Xu, Liu, Yaohua, Liu, Huailei, Chen, Xin, Liu, Min, Che, Hui, Guo, Fei, Wang, Chunlei, Zhang, Daming, Wu, Jianing, Chen, Xiaofeng, Shen, Chen, Li, Chenguang, Peng, Fei, Bi, Yunke, Yang, Zhuowen, Yang, Guang, Ai, Jing, Gao, Xin, Zhao, Shiguang
Format: Online
Language:English
Published: Nature Publishing Group 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4356960/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4356960/

Similar Items