Computational fluid dynamics applied to virtually deployed drug-eluting coronary bioresorbable scaffolds: Clinical translations derived from a proof-of-concept

Background: Three-dimensional design simulations of coronary metallic stents utilizing mathematical and computational algorithms have emerged as important tools for understanding biomechanical stent properties, predicting the interaction of the implanted platform with the adjacent tissue, and inform...

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Main Authors:	Gogas, Bill D., Yang, Boyi, Passerini, Tiziano, Veneziani, Alessandro, Piccinelli, Marina, Esposito, Gaetano, Rasoul-Arzrumly, Emad, Awad, Mosaab, Mekonnen, Girum, Hung, Olivia Y., Holloway, Beth, McDaniel, Michael, Giddens, Don, King, Spencer B., Samady, Habib
Format:	Online
Language:	English
Published:	Bloomsbury Qatar Foundation Journals 2014
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4355516/

id	pubmed-4355516
recordtype	oai_dc
spelling	pubmed-43555162015-03-16 Computational fluid dynamics applied to virtually deployed drug-eluting coronary bioresorbable scaffolds: Clinical translations derived from a proof-of-concept Gogas, Bill D. Yang, Boyi Passerini, Tiziano Veneziani, Alessandro Piccinelli, Marina Esposito, Gaetano Rasoul-Arzrumly, Emad Awad, Mosaab Mekonnen, Girum Hung, Olivia Y. Holloway, Beth McDaniel, Michael Giddens, Don King, Spencer B. Samady, Habib Research Article Background: Three-dimensional design simulations of coronary metallic stents utilizing mathematical and computational algorithms have emerged as important tools for understanding biomechanical stent properties, predicting the interaction of the implanted platform with the adjacent tissue, and informing stent design enhancements. Herein, we demonstrate the hemodynamic implications following virtual implantation of bioresorbable scaffolds using finite element methods and advanced computational fluid dynamics (CFD) simulations to visualize the device-flow interaction immediately after implantation and following scaffold resorption over time. Methods and Results: CFD simulations with time averaged wall shear stress (WSS) quantification following virtual bioresorbable scaffold deployment in idealized straight and curved geometries were performed. WSS was calculated at the inflow, endoluminal surface (top surface of the strut), and outflow of each strut surface post-procedure (stage I) and at a time point when 33% of scaffold resorption has occurred (stage II). The average WSS at stage I over the inflow and outflow surfaces was 3.2 and 3.1 dynes/cm2 respectively and 87.5 dynes/cm2 over endoluminal strut surface in the straight vessel. From stage I to stage II, WSS increased by 100% and 142% over the inflow and outflow surfaces, respectively, and decreased by 27% over the endoluminal strut surface. In a curved vessel, WSS change became more evident in the inner curvature with an increase of 63% over the inflow and 66% over the outflow strut surfaces. Similar analysis at the proximal and distal edges demonstrated a large increase of 486% at the lateral outflow surface of the proximal scaffold edge. Conclusions: The implementation of CFD simulations over virtually deployed bioresorbable scaffolds demonstrates the transient nature of device/flow interactions as the bioresorption process progresses over time. Such hemodynamic device modeling is expected to guide future bioresorbable scaffold design. Bloomsbury Qatar Foundation Journals 2014-12-31 /pmc/articles/PMC4355516/ /pubmed/25780796 http://dx.doi.org/10.5339/gcsp.2014.56 Text en © 2014 Gogas, Yang, Passerini, Veneziani, Piccinelli, Esposito, Rasoul-Arzrumly, Awad, Mekonnen, Hung, Holloway, McDaniel, Giddens, King III, Samady, licensee Bloomsbury Qatar Foundation Journals. This is an open access article distributed under the terms of the Creative Commons Attribution license CC BY 4.0, which permits unrestricted use, distribution and reproduction in any medium, provided the original work is properly cited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Gogas, Bill D. Yang, Boyi Passerini, Tiziano Veneziani, Alessandro Piccinelli, Marina Esposito, Gaetano Rasoul-Arzrumly, Emad Awad, Mosaab Mekonnen, Girum Hung, Olivia Y. Holloway, Beth McDaniel, Michael Giddens, Don King, Spencer B. Samady, Habib
spellingShingle	Gogas, Bill D. Yang, Boyi Passerini, Tiziano Veneziani, Alessandro Piccinelli, Marina Esposito, Gaetano Rasoul-Arzrumly, Emad Awad, Mosaab Mekonnen, Girum Hung, Olivia Y. Holloway, Beth McDaniel, Michael Giddens, Don King, Spencer B. Samady, Habib Computational fluid dynamics applied to virtually deployed drug-eluting coronary bioresorbable scaffolds: Clinical translations derived from a proof-of-concept
author_facet	Gogas, Bill D. Yang, Boyi Passerini, Tiziano Veneziani, Alessandro Piccinelli, Marina Esposito, Gaetano Rasoul-Arzrumly, Emad Awad, Mosaab Mekonnen, Girum Hung, Olivia Y. Holloway, Beth McDaniel, Michael Giddens, Don King, Spencer B. Samady, Habib
author_sort	Gogas, Bill D.
title	Computational fluid dynamics applied to virtually deployed drug-eluting coronary bioresorbable scaffolds: Clinical translations derived from a proof-of-concept
title_short	Computational fluid dynamics applied to virtually deployed drug-eluting coronary bioresorbable scaffolds: Clinical translations derived from a proof-of-concept
title_full	Computational fluid dynamics applied to virtually deployed drug-eluting coronary bioresorbable scaffolds: Clinical translations derived from a proof-of-concept
title_fullStr	Computational fluid dynamics applied to virtually deployed drug-eluting coronary bioresorbable scaffolds: Clinical translations derived from a proof-of-concept
title_full_unstemmed	Computational fluid dynamics applied to virtually deployed drug-eluting coronary bioresorbable scaffolds: Clinical translations derived from a proof-of-concept
title_sort	computational fluid dynamics applied to virtually deployed drug-eluting coronary bioresorbable scaffolds: clinical translations derived from a proof-of-concept
description	Background: Three-dimensional design simulations of coronary metallic stents utilizing mathematical and computational algorithms have emerged as important tools for understanding biomechanical stent properties, predicting the interaction of the implanted platform with the adjacent tissue, and informing stent design enhancements. Herein, we demonstrate the hemodynamic implications following virtual implantation of bioresorbable scaffolds using finite element methods and advanced computational fluid dynamics (CFD) simulations to visualize the device-flow interaction immediately after implantation and following scaffold resorption over time. Methods and Results: CFD simulations with time averaged wall shear stress (WSS) quantification following virtual bioresorbable scaffold deployment in idealized straight and curved geometries were performed. WSS was calculated at the inflow, endoluminal surface (top surface of the strut), and outflow of each strut surface post-procedure (stage I) and at a time point when 33% of scaffold resorption has occurred (stage II). The average WSS at stage I over the inflow and outflow surfaces was 3.2 and 3.1 dynes/cm2 respectively and 87.5 dynes/cm2 over endoluminal strut surface in the straight vessel. From stage I to stage II, WSS increased by 100% and 142% over the inflow and outflow surfaces, respectively, and decreased by 27% over the endoluminal strut surface. In a curved vessel, WSS change became more evident in the inner curvature with an increase of 63% over the inflow and 66% over the outflow strut surfaces. Similar analysis at the proximal and distal edges demonstrated a large increase of 486% at the lateral outflow surface of the proximal scaffold edge. Conclusions: The implementation of CFD simulations over virtually deployed bioresorbable scaffolds demonstrates the transient nature of device/flow interactions as the bioresorption process progresses over time. Such hemodynamic device modeling is expected to guide future bioresorbable scaffold design.
publisher	Bloomsbury Qatar Foundation Journals
publishDate	2014
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4355516/
_version_	1613197226662690816

Computational fluid dynamics applied to virtually deployed drug-eluting coronary bioresorbable scaffolds: Clinical translations derived from a proof-of-concept

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