Nitric Oxide Prevents Alveolar Senescence and Emphysema in a Mouse Model

Nitric Oxide Prevents Alveolar Senescence and Emphysema in a Mouse Model

Nω-nitro-L-arginine methyl ester (L-NAME) treatment induces arteriosclerosis and vascular senescence. Here, we report that the systemic inhibition of nitric oxide (NO) production by L-NAME causes pulmonary emphysema. L-NAME-treated lungs exhibited both the structural (alveolar tissue destruction) an...

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Bibliographic Details
Main Authors: Boe, Amanda E., Eren, Mesut, Morales-Nebreda, Luisa, Murphy, Sheila B., Budinger, G. R. Scott, Mutlu, Gökhan M., Miyata, Toshio, Vaughan, Douglas E.
Format: Online
Language:English
Published: Public Library of Science 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4355068/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4355068/

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