Cytotoxic effects of solvent-extracted active components of Salvia miltiorrhiza Bunge on human cancer cell lines

Herbal extracts and dietary supplements may be extracted from the medicinal plants used in traditional Chinese medicine, and are used increasingly commonly worldwide for their benefits to health and quality of life. Thus, ensuring that they are safe for human consumption is a critical issue for the...

Full description

Bibliographic Details
Main Authors:	SUNG, BOKYUNG, CHUNG, HYE SUN, KIM, MINJUNG, KANG, YONG JUNG, KIM, DONG HWAN, HWANG, SEONG YEON, KIM, MIN JO, KIM, CHEOL MIN, CHUNG, HAE YOUNG, KIM, NAM DEUK
Format:	Online
Language:	English
Published:	D.A. Spandidos 2015
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4353753/

id	pubmed-4353753
recordtype	oai_dc
spelling	pubmed-43537532015-03-16 Cytotoxic effects of solvent-extracted active components of Salvia miltiorrhiza Bunge on human cancer cell lines SUNG, BOKYUNG CHUNG, HYE SUN KIM, MINJUNG KANG, YONG JUNG KIM, DONG HWAN HWANG, SEONG YEON KIM, MIN JO KIM, CHEOL MIN CHUNG, HAE YOUNG KIM, NAM DEUK Articles Herbal extracts and dietary supplements may be extracted from the medicinal plants used in traditional Chinese medicine, and are used increasingly commonly worldwide for their benefits to health and quality of life. Thus, ensuring that they are safe for human consumption is a critical issue for the preparation of plant extracts as dietary supplements. The present study investigated extracts of Salvia miltiorrhiza Bunge (S. miltiorrhiza), traditionally used in Asian countries to treat a variety of conditions, as a dietary supplement or as an ingredient in functional foods. Dried S. miltiorrhiza root was extracted with various solvents and under varying extraction conditions, and the effects of the extracts on the viability of five human cancer cell lines were compared. Extracts obtained using 100% ethanol and 100% acetone as solvents exhibited more potent effects compared with extracts obtained using 70 and 30% aqueous ethanol. Furthermore, the active components of S. miltiorrhiza ethanol extracts, known as tanshinones, were investigated. Dihydrotanshinone I was observed to exhibit a higher cytotoxic potential compared with the other tanshinones in the majority of the examined cell lines. Conversely, cryptotanshinone exhibited weak anti-cancer activity. In summary, the results of the present study suggest that the active components obtained from an ethanol extract of S. miltiorrhiza possess the potential to be used as ingredients in functional and health care foods that may be used to improve the effectiveness of chemotherapeutics in the prevention and/or treatment of cancer. D.A. Spandidos 2015-04 2015-02-03 /pmc/articles/PMC4353753/ /pubmed/25780445 http://dx.doi.org/10.3892/etm.2015.2252 Text en Copyright © 2015, Spandidos Publications http://creativecommons.org/licenses/by/3.0 This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	SUNG, BOKYUNG CHUNG, HYE SUN KIM, MINJUNG KANG, YONG JUNG KIM, DONG HWAN HWANG, SEONG YEON KIM, MIN JO KIM, CHEOL MIN CHUNG, HAE YOUNG KIM, NAM DEUK
spellingShingle	SUNG, BOKYUNG CHUNG, HYE SUN KIM, MINJUNG KANG, YONG JUNG KIM, DONG HWAN HWANG, SEONG YEON KIM, MIN JO KIM, CHEOL MIN CHUNG, HAE YOUNG KIM, NAM DEUK Cytotoxic effects of solvent-extracted active components of Salvia miltiorrhiza Bunge on human cancer cell lines
author_facet	SUNG, BOKYUNG CHUNG, HYE SUN KIM, MINJUNG KANG, YONG JUNG KIM, DONG HWAN HWANG, SEONG YEON KIM, MIN JO KIM, CHEOL MIN CHUNG, HAE YOUNG KIM, NAM DEUK
author_sort	SUNG, BOKYUNG
title	Cytotoxic effects of solvent-extracted active components of Salvia miltiorrhiza Bunge on human cancer cell lines
title_short	Cytotoxic effects of solvent-extracted active components of Salvia miltiorrhiza Bunge on human cancer cell lines
title_full	Cytotoxic effects of solvent-extracted active components of Salvia miltiorrhiza Bunge on human cancer cell lines
title_fullStr	Cytotoxic effects of solvent-extracted active components of Salvia miltiorrhiza Bunge on human cancer cell lines
title_full_unstemmed	Cytotoxic effects of solvent-extracted active components of Salvia miltiorrhiza Bunge on human cancer cell lines
title_sort	cytotoxic effects of solvent-extracted active components of salvia miltiorrhiza bunge on human cancer cell lines
description	Herbal extracts and dietary supplements may be extracted from the medicinal plants used in traditional Chinese medicine, and are used increasingly commonly worldwide for their benefits to health and quality of life. Thus, ensuring that they are safe for human consumption is a critical issue for the preparation of plant extracts as dietary supplements. The present study investigated extracts of Salvia miltiorrhiza Bunge (S. miltiorrhiza), traditionally used in Asian countries to treat a variety of conditions, as a dietary supplement or as an ingredient in functional foods. Dried S. miltiorrhiza root was extracted with various solvents and under varying extraction conditions, and the effects of the extracts on the viability of five human cancer cell lines were compared. Extracts obtained using 100% ethanol and 100% acetone as solvents exhibited more potent effects compared with extracts obtained using 70 and 30% aqueous ethanol. Furthermore, the active components of S. miltiorrhiza ethanol extracts, known as tanshinones, were investigated. Dihydrotanshinone I was observed to exhibit a higher cytotoxic potential compared with the other tanshinones in the majority of the examined cell lines. Conversely, cryptotanshinone exhibited weak anti-cancer activity. In summary, the results of the present study suggest that the active components obtained from an ethanol extract of S. miltiorrhiza possess the potential to be used as ingredients in functional and health care foods that may be used to improve the effectiveness of chemotherapeutics in the prevention and/or treatment of cancer.
publisher	D.A. Spandidos
publishDate	2015
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4353753/
_version_	1613196640710033408

Cytotoxic effects of solvent-extracted active components of Salvia miltiorrhiza Bunge on human cancer cell lines

Similar Items