XRN1 Stalling in the 5’ UTR of Hepatitis C Virus and Bovine Viral Diarrhea Virus Is Associated with Dysregulated Host mRNA Stability

XRN1 Stalling in the 5’ UTR of Hepatitis C Virus and Bovine Viral Diarrhea Virus Is Associated with Dysregulated Host mRNA Stability

We demonstrate that both Hepatitis C virus (HCV) and Bovine Viral Diarrhea virus (BVDV) contain regions in their 5’ UTRs that stall and repress the enzymatic activity of the cellular 5’-3’ exoribonuclease XRN1, resulting in dramatic changes in the stability of cellular mRNAs. We used biochemical ass...

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Bibliographic Details
Main Authors: Moon, Stephanie L., Blackinton, Jeffrey G., Anderson, John R., Dozier, Mary K., Dodd, Benjamin J. T., Keene, Jack D., Wilusz, Carol J., Bradrick, Shelton S., Wilusz, Jeffrey
Format: Online
Language:English
Published: Public Library of Science 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4352041/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4352041/

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