Measurement of real pulsatile blood flow using X-ray PIV technique with CO2 microbubbles

Synchrotron X-ray imaging technique has been used to investigate biofluid flows in a non-destructive manner. This study aims to investigate the feasibility of the X-ray PIV technique with CO2 microbubbles as flow tracer for measurement of pulsatile blood flows under in vivo conditions. The traceabil...

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Main Authors:	Park, Hanwook, Yeom, Eunseop, Seo, Seung-Jun, Lim, Jae-Hong, Lee, Sang-Joon
Format:	Online
Language:	English
Published:	Nature Publishing Group 2015
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4351547/

id	pubmed-4351547
recordtype	oai_dc
spelling	pubmed-43515472015-03-10 Measurement of real pulsatile blood flow using X-ray PIV technique with CO2 microbubbles Park, Hanwook Yeom, Eunseop Seo, Seung-Jun Lim, Jae-Hong Lee, Sang-Joon Article Synchrotron X-ray imaging technique has been used to investigate biofluid flows in a non-destructive manner. This study aims to investigate the feasibility of the X-ray PIV technique with CO2 microbubbles as flow tracer for measurement of pulsatile blood flows under in vivo conditions. The traceability of CO2 microbubbles in a pulsatile flow was demonstrated through in vitro experiment. A rat extracorporeal bypass loop was used by connecting a tube between the abdominal aorta and jugular vein of a rat to obtain hemodynamic information of actual pulsatile blood flows without changing the hemorheological properties. The decrease in image contrast of the surrounding tissue was also investigated for in vivo applications of the proposed technique. This technique could be used to accurately measure whole velocity field information of real pulsatile blood flows and has strong potential for hemodynamic diagnosis of cardiovascular diseases. Nature Publishing Group 2015-03-06 /pmc/articles/PMC4351547/ /pubmed/25744850 http://dx.doi.org/10.1038/srep08840 Text en Copyright © 2015, Macmillan Publishers Limited. All rights reserved http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder in order to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Park, Hanwook Yeom, Eunseop Seo, Seung-Jun Lim, Jae-Hong Lee, Sang-Joon
spellingShingle	Park, Hanwook Yeom, Eunseop Seo, Seung-Jun Lim, Jae-Hong Lee, Sang-Joon Measurement of real pulsatile blood flow using X-ray PIV technique with CO2 microbubbles
author_facet	Park, Hanwook Yeom, Eunseop Seo, Seung-Jun Lim, Jae-Hong Lee, Sang-Joon
author_sort	Park, Hanwook
title	Measurement of real pulsatile blood flow using X-ray PIV technique with CO2 microbubbles
title_short	Measurement of real pulsatile blood flow using X-ray PIV technique with CO2 microbubbles
title_full	Measurement of real pulsatile blood flow using X-ray PIV technique with CO2 microbubbles
title_fullStr	Measurement of real pulsatile blood flow using X-ray PIV technique with CO2 microbubbles
title_full_unstemmed	Measurement of real pulsatile blood flow using X-ray PIV technique with CO2 microbubbles
title_sort	measurement of real pulsatile blood flow using x-ray piv technique with co2 microbubbles
description	Synchrotron X-ray imaging technique has been used to investigate biofluid flows in a non-destructive manner. This study aims to investigate the feasibility of the X-ray PIV technique with CO2 microbubbles as flow tracer for measurement of pulsatile blood flows under in vivo conditions. The traceability of CO2 microbubbles in a pulsatile flow was demonstrated through in vitro experiment. A rat extracorporeal bypass loop was used by connecting a tube between the abdominal aorta and jugular vein of a rat to obtain hemodynamic information of actual pulsatile blood flows without changing the hemorheological properties. The decrease in image contrast of the surrounding tissue was also investigated for in vivo applications of the proposed technique. This technique could be used to accurately measure whole velocity field information of real pulsatile blood flows and has strong potential for hemodynamic diagnosis of cardiovascular diseases.
publisher	Nature Publishing Group
publishDate	2015
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4351547/
_version_	1613195881637478400

Measurement of real pulsatile blood flow using X-ray PIV technique with CO2 microbubbles

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