Mechanism of Microhomology-Mediated End-Joining Promoted by Human DNA Polymerase Theta
Microhomology-mediated end-joining (MMEJ) is an error-prone alternative double-strand break repair pathway that utilizes sequence microhomology to recombine broken DNA. Although MMEJ is implicated in cancer development, the mechanism of this pathway is unknown. We demonstrate that purified human DNA...
| Main Authors: | , , , , |
|---|---|
| Format: | Online |
| Language: | English |
| Published: |
2015
|
| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4351179/ |