YSY01A, a Novel Proteasome Inhibitor, Induces Cell Cycle Arrest on G2 Phase in MCF-7 Cells via ERα and PI3K/Akt Pathways

Given that the proteasome is essential for multiple cellular processes by degrading diverse regulatory proteins, inhibition of the proteasome has emerged as an attractive target for anti-cancer therapy. YSY01A is a novel small molecule compound targeting the proteasome. The compound was found to sup...

Full description

Bibliographic Details
Main Authors: Xue, Bingjie, Huang, Wei, Yuan, Xia, Xu, Bo, Lou, Yaxin, Zhou, Quan, Ran, Fuxiang, Ge, Zemei, Li, Runtao, Cui, Jingrong
Format: Online
Language:English
Published: Ivyspring International Publisher 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4349871/