Overexpression of the Transcription Factor Sp1 Activates the OAS-RNAse L-RIG-I Pathway

Overexpression of the Transcription Factor Sp1 Activates the OAS-RNAse L-RIG-I Pathway

Deregulated expression of oncogenes or transcription factors such as specificity protein 1 (Sp1) is observed in many human cancers and plays a role in tumor maintenance. Paradoxically in untransformed cells, Sp1 overexpression induces late apoptosis but the early intrinsic response is poorly charact...

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Bibliographic Details
Main Authors: Dupuis-Maurin, Valéryane, Brinza, Lilia, Baguet, Joël, Plantamura, Emilie, Schicklin, Stéphane, Chambion, Solène, Macari, Claire, Tomkowiak, Martine, Deniaud, Emmanuelle, Leverrier, Yann, Marvel, Jacqueline, Michallet, Marie-Cécile
Format: Online
Language:English
Published: Public Library of Science 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4349862/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4349862/

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