TGF-β3-expressing CD4+CD25−LAG3+ regulatory T cells control humoral immune responses

TGF-β3-expressing CD4+CD25−LAG3+ regulatory T cells control humoral immune responses

Autoantibodies induce various autoimmune diseases, including systemic lupus erythematosus (SLE). We previously described that CD4+CD25−LAG3+ regulatory T cells (LAG3+ Treg) are regulated by Egr2, a zinc-finger transcription factor required for the induction of T-cell anergy. We herein demonstrate th...

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Bibliographic Details
Main Authors: Okamura, Tomohisa, Sumitomo, Shuji, Morita, Kaoru, Iwasaki, Yukiko, Inoue, Mariko, Nakachi, Shinichiro, Komai, Toshihiko, Shoda, Hirofumi, Miyazaki, Jun-ichi, Fujio, Keishi, Yamamoto, Kazuhiko
Format: Online
Language:English
Published: Nature Pub. Group 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4346620/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4346620/

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