The activity of cAMP-phosphodiesterase 4D7 (PDE4D7) is regulated by protein kinase A-dependent phosphorylation within its unique N-terminus
•PDE4D7 is phosphorylated by PKA in the unique N-terminal region at serine 42.•PDE4D7 phosphorylation at serine 42 negatively regulates PDE4 activity.•Ablation of phosphorylation at serine 42 activates PDE4D7 and this reduces phosphorylation in the UCR1 domain.
| Main Authors: | , , , |
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| Format: | Online |
| Language: | English |
| Published: |
Elsevier Science B.V
2015
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4346272/ |