Proof-of-concept Studies for siRNA-mediated Gene Silencing for Coagulation Factors in Rat and Rabbit

Proof-of-concept Studies for siRNA-mediated Gene Silencing for Coagulation Factors in Rat and Rabbit

The present study aimed at establishing feasibility of delivering short interfering RNA (siRNA) to target the coagulation cascade in rat and rabbit, two commonly used species for studying thrombosis and hemostasis. siRNAs that produced over 90% mRNA knockdown of rat plasma prekallikrein and rabbit F...

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Bibliographic Details
Main Authors: Chen, Zhu, Luo, Bin, Cai, Tian-Quan, Thankappan, Anil, Xu, Yiming, Wu, Weizhen, DiMuzio, Jillian, Lifsted, Traci, DiPietro, Marty, Disa, Jyoti, Ng, Bruce, Leander, Karen, Clark, Seth, Hoos, Lizbeth, Zhou, Yuchen, Jochnowitz, Nina, Jachec, Christine, Szczerba, Peter, Gindy, Marian E., Strapps, Walter, Sepp-Lorenzino, Laura, Seiffert, Dietmar A., Lubbers, Laura, Tadin-Strapps, Marija
Format: Online
Language:English
Published: Nature Publishing Group 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4345307/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4345307/

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