Protein Sectors: Statistical Coupling Analysis versus Conservation

Statistical coupling analysis (SCA) is a method for analyzing multiple sequence alignments that was used to identify groups of coevolving residues termed “sectors”. The method applies spectral analysis to a matrix obtained by combining correlation information with sequence conservation. It has been...

Full description

Bibliographic Details
Main Authors: Teşileanu, Tiberiu, Colwell, Lucy J., Leibler, Stanislas
Format: Online
Language:English
Published: Public Library of Science 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4344308/