Interleukin-1 loop model for pathogenesis of Langerhans cell histiocytosis

Interleukin-1 loop model for pathogenesis of Langerhans cell histiocytosis

We propose Langerhans cell histiocytosis (LCH) is an inflammatory process that is prolonged by mutations. We hypothesize that Merkel cell polyomavirus (MCPyV) infection triggers an interleukin-1 (IL-1) activation loop that underlies the pathogenesis of LCH. Langerhans cells (LCs) are antigen present...

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Bibliographic Details
Main Authors: Murakami, Ichiro, Matsushita, Michiko, Iwasaki, Takeshi, Kuwamoto, Satoshi, Kato, Masako, Nagata, Keiko, Horie, Yasushi, Hayashi, Kazuhiko, Imamura, Toshihiko, Morimoto, Akira, Imashuku, Shinsaku, Gogusev, Jean, Jaubert, Francis, Takata, Katsuyoshi, Oka, Takashi, Yoshino, Tadashi
Format: Online
Language:English
Published: BioMed Central 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4343072/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4343072/

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