Earliest Holozoan Expansion of Phosphotyrosine Signaling

Phosphotyrosine (pTyr) signaling is involved in development and maintenance of metazoans’ multicellular body through cell-to-cell communication. Tyrosine kinases (TKs), tyrosine phosphatases, and other proteins relaying the signal compose the cascade. Domain architectures of the pTyr signaling prote...

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Main Authors:	Suga, Hiroshi, Torruella, Guifré, Burger, Gertraud, Brown, Matthew W., Ruiz-Trillo, Iñaki
Format:	Online
Language:	English
Published:	2013
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4342544/

id	pubmed-4342544
recordtype	oai_dc
spelling	pubmed-43425442015-02-27 Earliest Holozoan Expansion of Phosphotyrosine Signaling Suga, Hiroshi Torruella, Guifré Burger, Gertraud Brown, Matthew W. Ruiz-Trillo, Iñaki Article Phosphotyrosine (pTyr) signaling is involved in development and maintenance of metazoans’ multicellular body through cell-to-cell communication. Tyrosine kinases (TKs), tyrosine phosphatases, and other proteins relaying the signal compose the cascade. Domain architectures of the pTyr signaling proteins are diverse in metazoans, reflecting their complex intercellular communication. Previous studies had shown that the metazoan-type TKs, as well as other pTyr signaling proteins, were already diversified in the common ancestor of metazoans, choanoflagellates, and filastereans (which are together included in the clade Holozoa) whereas they are absent in fungi and other nonholozoan lineages. However, the earliest-branching holozoans Ichthyosporea and Corallochytrea, as well as the two fungi-related amoebae Fonticula and Nuclearia, have not been studied. Here, we analyze the complete genome sequences of two ichthyosporeans and Fonticula, and RNAseq data of three additional ichthyosporeans, one corallochytrean, and Nuclearia. Both the ichthyosporean and corallochytrean genomes encode a large variety of receptor TKs (RTKs) and cytoplasmic TKs (CTKs), as well as other pTyr signaling components showing highly complex domain architectures. However, Nuclearia and Fonticula have no TK, and show much less diversity in other pTyr signaling components. The CTK repertoires of both Ichthyosporea and Corallochytrea are similar to those of Metazoa, Choanoflagellida, and Filasterea, but the RTK sets are totally different from each other. The complex pTyr signaling equipped with positive/negative feedback mechanism likely emerged already at an early stage of holozoan evolution, yet keeping a high evolutionary plasticity in extracellular signal reception until the co-option of the system for cell-to-cell communication in metazoans. 2013-12-03 2014-03 /pmc/articles/PMC4342544/ /pubmed/24307687 http://dx.doi.org/10.1093/molbev/mst241 Text en © The Author 2013. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Suga, Hiroshi Torruella, Guifré Burger, Gertraud Brown, Matthew W. Ruiz-Trillo, Iñaki
spellingShingle	Suga, Hiroshi Torruella, Guifré Burger, Gertraud Brown, Matthew W. Ruiz-Trillo, Iñaki Earliest Holozoan Expansion of Phosphotyrosine Signaling
author_facet	Suga, Hiroshi Torruella, Guifré Burger, Gertraud Brown, Matthew W. Ruiz-Trillo, Iñaki
author_sort	Suga, Hiroshi
title	Earliest Holozoan Expansion of Phosphotyrosine Signaling
title_short	Earliest Holozoan Expansion of Phosphotyrosine Signaling
title_full	Earliest Holozoan Expansion of Phosphotyrosine Signaling
title_fullStr	Earliest Holozoan Expansion of Phosphotyrosine Signaling
title_full_unstemmed	Earliest Holozoan Expansion of Phosphotyrosine Signaling
title_sort	earliest holozoan expansion of phosphotyrosine signaling
description	Phosphotyrosine (pTyr) signaling is involved in development and maintenance of metazoans’ multicellular body through cell-to-cell communication. Tyrosine kinases (TKs), tyrosine phosphatases, and other proteins relaying the signal compose the cascade. Domain architectures of the pTyr signaling proteins are diverse in metazoans, reflecting their complex intercellular communication. Previous studies had shown that the metazoan-type TKs, as well as other pTyr signaling proteins, were already diversified in the common ancestor of metazoans, choanoflagellates, and filastereans (which are together included in the clade Holozoa) whereas they are absent in fungi and other nonholozoan lineages. However, the earliest-branching holozoans Ichthyosporea and Corallochytrea, as well as the two fungi-related amoebae Fonticula and Nuclearia, have not been studied. Here, we analyze the complete genome sequences of two ichthyosporeans and Fonticula, and RNAseq data of three additional ichthyosporeans, one corallochytrean, and Nuclearia. Both the ichthyosporean and corallochytrean genomes encode a large variety of receptor TKs (RTKs) and cytoplasmic TKs (CTKs), as well as other pTyr signaling components showing highly complex domain architectures. However, Nuclearia and Fonticula have no TK, and show much less diversity in other pTyr signaling components. The CTK repertoires of both Ichthyosporea and Corallochytrea are similar to those of Metazoa, Choanoflagellida, and Filasterea, but the RTK sets are totally different from each other. The complex pTyr signaling equipped with positive/negative feedback mechanism likely emerged already at an early stage of holozoan evolution, yet keeping a high evolutionary plasticity in extracellular signal reception until the co-option of the system for cell-to-cell communication in metazoans.
publishDate	2013
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4342544/
_version_	1613193198886191104

Earliest Holozoan Expansion of Phosphotyrosine Signaling

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