The functional sites of miRNAs and lncRNAs in gastric carcinogenesis

Gastric cancer is one of the most common malignant diseases and has one of the highest mortality rates worldwide. Its molecular mechanisms are poorly understood. Recently, the functions of non-coding RNAs (ncRNAs) in gastric cancer have attracted wide attention. Although the expression levels of var...

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Main Authors:	Wan, Xiangxiang, Ding, Xiaoyun, Chen, Shengcan, Song, Haojun, Jiang, Haizhong, Fang, Ying, Li, Peifei, Guo, Junming
Format:	Online
Language:	English
Published:	Springer Netherlands 2015
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4342515/

id	pubmed-4342515
recordtype	oai_dc
spelling	pubmed-43425152015-03-04 The functional sites of miRNAs and lncRNAs in gastric carcinogenesis Wan, Xiangxiang Ding, Xiaoyun Chen, Shengcan Song, Haojun Jiang, Haizhong Fang, Ying Li, Peifei Guo, Junming Review Gastric cancer is one of the most common malignant diseases and has one of the highest mortality rates worldwide. Its molecular mechanisms are poorly understood. Recently, the functions of non-coding RNAs (ncRNAs) in gastric cancer have attracted wide attention. Although the expression levels of various ncRNAs are different, they may work together in a network and contribute to gastric carcinogenesis by altering the expression of oncogenes or tumor suppressor genes. They affect the cell cycle, apoptosis, motility, invasion, and metastasis. Dysregulated microRNAs (miRNAs) and long non-coding RNAs (lncRNAs), including miR-21, miR-106, H19, and ANRIL, directly or indirectly regulate carcinogenic factors or signaling pathways such as PTEN, CDK, caspase, E-cadherin, Akt, and P53. Greater recognition of the roles of miRNAs and lncRNAs in gastric carcinogenesis can provide new insight into the mechanisms of tumor development and identify targets for anticancer drug development. Springer Netherlands 2015-02-01 /pmc/articles/PMC4342515/ /pubmed/25636450 http://dx.doi.org/10.1007/s13277-015-3136-5 Text en © The Author(s) 2015 Open Access This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Wan, Xiangxiang Ding, Xiaoyun Chen, Shengcan Song, Haojun Jiang, Haizhong Fang, Ying Li, Peifei Guo, Junming
spellingShingle	Wan, Xiangxiang Ding, Xiaoyun Chen, Shengcan Song, Haojun Jiang, Haizhong Fang, Ying Li, Peifei Guo, Junming The functional sites of miRNAs and lncRNAs in gastric carcinogenesis
author_facet	Wan, Xiangxiang Ding, Xiaoyun Chen, Shengcan Song, Haojun Jiang, Haizhong Fang, Ying Li, Peifei Guo, Junming
author_sort	Wan, Xiangxiang
title	The functional sites of miRNAs and lncRNAs in gastric carcinogenesis
title_short	The functional sites of miRNAs and lncRNAs in gastric carcinogenesis
title_full	The functional sites of miRNAs and lncRNAs in gastric carcinogenesis
title_fullStr	The functional sites of miRNAs and lncRNAs in gastric carcinogenesis
title_full_unstemmed	The functional sites of miRNAs and lncRNAs in gastric carcinogenesis
title_sort	functional sites of mirnas and lncrnas in gastric carcinogenesis
description	Gastric cancer is one of the most common malignant diseases and has one of the highest mortality rates worldwide. Its molecular mechanisms are poorly understood. Recently, the functions of non-coding RNAs (ncRNAs) in gastric cancer have attracted wide attention. Although the expression levels of various ncRNAs are different, they may work together in a network and contribute to gastric carcinogenesis by altering the expression of oncogenes or tumor suppressor genes. They affect the cell cycle, apoptosis, motility, invasion, and metastasis. Dysregulated microRNAs (miRNAs) and long non-coding RNAs (lncRNAs), including miR-21, miR-106, H19, and ANRIL, directly or indirectly regulate carcinogenic factors or signaling pathways such as PTEN, CDK, caspase, E-cadherin, Akt, and P53. Greater recognition of the roles of miRNAs and lncRNAs in gastric carcinogenesis can provide new insight into the mechanisms of tumor development and identify targets for anticancer drug development.
publisher	Springer Netherlands
publishDate	2015
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4342515/
_version_	1613193182993973248

The functional sites of miRNAs and lncRNAs in gastric carcinogenesis

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