Alpha-fetoprotein activates AKT/mTOR signaling to promote CXCR4 expression and migration of hepatoma cells

Alpha-fetoprotein activates AKT/mTOR signaling to promote CXCR4 expression and migration of hepatoma cells

CXCR4, stromal cell-derived factor-1α(SDF 1α) receptor, stimulates growth and metastasis of hepatocellular carcinoma (HCC). Alpha-fetoprotein(AFP) governs the expression of some metastasis-related genes. Here we report that AFP and CXCR4 levels correlated in HCC tissues. AFP-expressing vectors induc...

Full description

Bibliographic Details
Main Authors: Zhu, Mingyue, Guo, Junli, Xia, Hua, Li, Wei, Lu, Yan, Dong, Xu, Chen, Yi, Xie, Xieju, Fu, Shigan, Li, Mengsen
Format: Online
Language:English
Published: Impact Journals LLC 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4341465/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4341465/

Similar Items