USP45 deubiquitylase controls ERCC1–XPF endonuclease-mediated DNA damage responses

USP45 deubiquitylase controls ERCC1–XPF endonuclease-mediated DNA damage responses

Reversible protein ubiquitylation plays important roles in various processes including DNA repair. Here, we identify the deubiquitylase USP45 as a critical DNA repair regulator. USP45 associates with ERCC1, a subunit of the DNA repair endonuclease XPF–ERCC1, via a short acidic motif outside of the U...

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Bibliographic Details
Main Authors: Perez-Oliva, Ana B, Lachaud, Christophe, Szyniarowski, Piotr, Muñoz, Ivan, Macartney, Thomas, Hickson, Ian, Rouse, John, Alessi, Dario R
Format: Online
Language:English
Published: BlackWell Publishing Ltd 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4339120/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4339120/

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