Using Regional Homogeneity to Reveal Altered Spontaneous Activity in Patients with Mild Cognitive Impairment

Using Regional Homogeneity to Reveal Altered Spontaneous Activity in Patients with Mild Cognitive Impairment

Most patients with mild cognitive impairment (MCI) are thought to be in an early stage of Alzheimer's disease (AD). Resting-state functional magnetic resonance imaging reflects spontaneous brain activity and/or the endogenous/background neurophysiological process of the human brain. Regional ho...

Full description

Bibliographic Details
Main Authors: Wang, Yumei, Zhao, Xiaochuan, Xu, Shunjiang, Yu, Lulu, Wang, Lan, Song, Mei, Yang, Linlin, Wang, Xueyi
Format: Online
Language:English
Published: Hindawi Publishing Corporation 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4337114/
id pubmed-4337114
recordtype oai_dc
spelling pubmed-43371142015-03-03 Using Regional Homogeneity to Reveal Altered Spontaneous Activity in Patients with Mild Cognitive Impairment Wang, Yumei Zhao, Xiaochuan Xu, Shunjiang Yu, Lulu Wang, Lan Song, Mei Yang, Linlin Wang, Xueyi Research Article Most patients with mild cognitive impairment (MCI) are thought to be in an early stage of Alzheimer's disease (AD). Resting-state functional magnetic resonance imaging reflects spontaneous brain activity and/or the endogenous/background neurophysiological process of the human brain. Regional homogeneity (ReHo) rapidly maps regional brain activity across the whole brain. In the present study, we used the ReHo index to explore whole brain spontaneous activity pattern in MCI. Our results showed that MCI subjects displayed an increased ReHo index in the paracentral lobe, precuneus, and postcentral and a decreased ReHo index in the medial temporal gyrus and hippocampus. Impairments in the medial temporal gyrus and hippocampus may serve as important markers distinguishing MCI from healthy aging. Moreover, the increased ReHo index observed in the postcentral and paracentral lobes might indicate compensation for the cognitive function losses in individuals with MCI. Hindawi Publishing Corporation 2015 2015-02-09 /pmc/articles/PMC4337114/ /pubmed/25738156 http://dx.doi.org/10.1155/2015/807093 Text en Copyright © 2015 Yumei Wang et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
repository_type Open Access Journal
institution_category Foreign Institution
institution US National Center for Biotechnology Information
building NCBI PubMed
collection Online Access
language English
format Online
author Wang, Yumei
Zhao, Xiaochuan
Xu, Shunjiang
Yu, Lulu
Wang, Lan
Song, Mei
Yang, Linlin
Wang, Xueyi
spellingShingle Wang, Yumei
Zhao, Xiaochuan
Xu, Shunjiang
Yu, Lulu
Wang, Lan
Song, Mei
Yang, Linlin
Wang, Xueyi
Using Regional Homogeneity to Reveal Altered Spontaneous Activity in Patients with Mild Cognitive Impairment
author_facet Wang, Yumei
Zhao, Xiaochuan
Xu, Shunjiang
Yu, Lulu
Wang, Lan
Song, Mei
Yang, Linlin
Wang, Xueyi
author_sort Wang, Yumei
title Using Regional Homogeneity to Reveal Altered Spontaneous Activity in Patients with Mild Cognitive Impairment
title_short Using Regional Homogeneity to Reveal Altered Spontaneous Activity in Patients with Mild Cognitive Impairment
title_full Using Regional Homogeneity to Reveal Altered Spontaneous Activity in Patients with Mild Cognitive Impairment
title_fullStr Using Regional Homogeneity to Reveal Altered Spontaneous Activity in Patients with Mild Cognitive Impairment
title_full_unstemmed Using Regional Homogeneity to Reveal Altered Spontaneous Activity in Patients with Mild Cognitive Impairment
title_sort using regional homogeneity to reveal altered spontaneous activity in patients with mild cognitive impairment
description Most patients with mild cognitive impairment (MCI) are thought to be in an early stage of Alzheimer's disease (AD). Resting-state functional magnetic resonance imaging reflects spontaneous brain activity and/or the endogenous/background neurophysiological process of the human brain. Regional homogeneity (ReHo) rapidly maps regional brain activity across the whole brain. In the present study, we used the ReHo index to explore whole brain spontaneous activity pattern in MCI. Our results showed that MCI subjects displayed an increased ReHo index in the paracentral lobe, precuneus, and postcentral and a decreased ReHo index in the medial temporal gyrus and hippocampus. Impairments in the medial temporal gyrus and hippocampus may serve as important markers distinguishing MCI from healthy aging. Moreover, the increased ReHo index observed in the postcentral and paracentral lobes might indicate compensation for the cognitive function losses in individuals with MCI.
publisher Hindawi Publishing Corporation
publishDate 2015
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4337114/
_version_ 1613191368781332480

Similar Items