Pooled Sequencing of 531 Genes in Inflammatory Bowel Disease Identifies an Associated Rare Variant in BTNL2 and Implicates Other Immune Related Genes

Pooled Sequencing of 531 Genes in Inflammatory Bowel Disease Identifies an Associated Rare Variant in BTNL2 and Implicates Other Immune Related Genes

The contribution of rare coding sequence variants to genetic susceptibility in complex disorders is an important but unresolved question. Most studies thus far have investigated a limited number of genes from regions which contain common disease associated variants. Here we investigate this in infla...

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Bibliographic Details
Main Authors: Prescott, Natalie J., Lehne, Benjamin, Stone, Kristina, Lee, James C., Taylor, Kirstin, Knight, Jo, Papouli, Efterpi, Mirza, Muddassar M., Simpson, Michael A., Spain, Sarah L., Lu, Grace, Fraternali, Franca, Bumpstead, Suzannah J., Gray, Emma, Amar, Ariella, Bye, Hannah, Green, Peter, Chung-Faye, Guy, Hayee, Bu’Hussain, Pollok, Richard, Satsangi, Jack, Parkes, Miles, Barrett, Jeffrey C., Mansfield, John C., Sanderson, Jeremy, Lewis, Cathryn M., Weale, Michael E., Schlitt, Thomas, Mathew, Christopher G.
Format: Online
Language:English
Published: Public Library of Science 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4335459/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4335459/

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