A modular system of DNA enhancer elements mediates tissue-specific activation of transcription by high dietary zinc in C. elegans

Zinc is essential for biological systems, and aberrant zinc metabolism is implicated in a broad range of human diseases. To maintain homeostasis in response to fluctuating levels of dietary zinc, animals regulate gene expression; however, mechanisms that mediate the transcriptional response to fluct...

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Bibliographic Details
Main Authors: Roh, Hyun Cheol, Dimitrov, Ivan, Deshmukh, Krupa, Zhao, Guoyan, Warnhoff, Kurt, Cabrera, Daniel, Tsai, Wendy, Kornfeld, Kerry
Format: Online
Language:English
Published: Oxford University Press 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4333406/