TNF-α and TNFR1 responses to recovery therapies following acute resistance exercise

The purpose of this investigation was to compare the effect of two commonly used therapeutic modalities (a) neuromuscular electrical stimulation (NMES) and (b) cold water immersion (CWI) on circulating tumor necrosis factor alpha (TNF-α) and monocyte TNF-α receptor (TNFR1) expression following inten...

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Main Authors:	Townsend, Jeremy R., Hoffman, Jay R., Fragala, Maren S., Jajtner, Adam R., Gonzalez, Adam M., Wells, Adam J., Mangine, Gerald T., Fukuda, David H., Stout, Jeffrey R.
Format:	Online
Language:	English
Published:	Frontiers Media S.A. 2015
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4332300/

id	pubmed-4332300
recordtype	oai_dc
spelling	pubmed-43323002015-03-04 TNF-α and TNFR1 responses to recovery therapies following acute resistance exercise Townsend, Jeremy R. Hoffman, Jay R. Fragala, Maren S. Jajtner, Adam R. Gonzalez, Adam M. Wells, Adam J. Mangine, Gerald T. Fukuda, David H. Stout, Jeffrey R. Physiology The purpose of this investigation was to compare the effect of two commonly used therapeutic modalities (a) neuromuscular electrical stimulation (NMES) and (b) cold water immersion (CWI) on circulating tumor necrosis factor alpha (TNF-α) and monocyte TNF-α receptor (TNFR1) expression following intense acute resistance exercise and subsequent recovery. Thirty (n = 30) resistance trained men (22.5 ± 2.7 y) performed an acute heavy resistance exercise protocol on three consecutive days followed by one of three recovery methods (CON, NMES, and CWI). Circulating TNF-α levels were assayed and TNFR1 expression on CD14+ monocytes was measured by flow cytometry measured PRE, immediately post (IP), 30-min post (30M), 24 h post (24H), and 48 h post (48H) exercise. Circulating TNF-α was elevated at IP (p = 0.001) and 30M (p = 0.005) and decreased at 24H and 48H recovery from IP in CON (p = 0.015) and CWI (p = 0.011). TNF-α did not significantly decrease from IP during recovery in NMES. TNFR1 expression was elevated (p < 0.001) at 30M compared to PRE and all other time points. No significant differences between groups were observed in TNFR1 expression. During recovery (24H, 48H) from muscle damaging exercise, NMES treatment appears to prevent the decline in circulating TNF-α observed during recovery in those receiving no treatment or CWI. Frontiers Media S.A. 2015-02-18 /pmc/articles/PMC4332300/ /pubmed/25741287 http://dx.doi.org/10.3389/fphys.2015.00048 Text en Copyright © 2015 Townsend, Hoffman, Fragala, Jajtner, Gonzalez, Wells, Mangine, Fukuda and Stout. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Townsend, Jeremy R. Hoffman, Jay R. Fragala, Maren S. Jajtner, Adam R. Gonzalez, Adam M. Wells, Adam J. Mangine, Gerald T. Fukuda, David H. Stout, Jeffrey R.
spellingShingle	Townsend, Jeremy R. Hoffman, Jay R. Fragala, Maren S. Jajtner, Adam R. Gonzalez, Adam M. Wells, Adam J. Mangine, Gerald T. Fukuda, David H. Stout, Jeffrey R. TNF-α and TNFR1 responses to recovery therapies following acute resistance exercise
author_facet	Townsend, Jeremy R. Hoffman, Jay R. Fragala, Maren S. Jajtner, Adam R. Gonzalez, Adam M. Wells, Adam J. Mangine, Gerald T. Fukuda, David H. Stout, Jeffrey R.
author_sort	Townsend, Jeremy R.
title	TNF-α and TNFR1 responses to recovery therapies following acute resistance exercise
title_short	TNF-α and TNFR1 responses to recovery therapies following acute resistance exercise
title_full	TNF-α and TNFR1 responses to recovery therapies following acute resistance exercise
title_fullStr	TNF-α and TNFR1 responses to recovery therapies following acute resistance exercise
title_full_unstemmed	TNF-α and TNFR1 responses to recovery therapies following acute resistance exercise
title_sort	tnf-α and tnfr1 responses to recovery therapies following acute resistance exercise
description	The purpose of this investigation was to compare the effect of two commonly used therapeutic modalities (a) neuromuscular electrical stimulation (NMES) and (b) cold water immersion (CWI) on circulating tumor necrosis factor alpha (TNF-α) and monocyte TNF-α receptor (TNFR1) expression following intense acute resistance exercise and subsequent recovery. Thirty (n = 30) resistance trained men (22.5 ± 2.7 y) performed an acute heavy resistance exercise protocol on three consecutive days followed by one of three recovery methods (CON, NMES, and CWI). Circulating TNF-α levels were assayed and TNFR1 expression on CD14+ monocytes was measured by flow cytometry measured PRE, immediately post (IP), 30-min post (30M), 24 h post (24H), and 48 h post (48H) exercise. Circulating TNF-α was elevated at IP (p = 0.001) and 30M (p = 0.005) and decreased at 24H and 48H recovery from IP in CON (p = 0.015) and CWI (p = 0.011). TNF-α did not significantly decrease from IP during recovery in NMES. TNFR1 expression was elevated (p < 0.001) at 30M compared to PRE and all other time points. No significant differences between groups were observed in TNFR1 expression. During recovery (24H, 48H) from muscle damaging exercise, NMES treatment appears to prevent the decline in circulating TNF-α observed during recovery in those receiving no treatment or CWI.
publisher	Frontiers Media S.A.
publishDate	2015
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4332300/
_version_	1613189751282597888

TNF-α and TNFR1 responses to recovery therapies following acute resistance exercise

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