Ovalbumin sensitization of guinea pig at birth prevents the ontogenetic decrease in airway smooth muscle responsiveness

Airway smooth muscle (ASM) displays a hyperresponsive phenotype at young age and becomes less responsive in adulthood. We hypothesized that allergic sensitization, which causes ASM hyperresponsiveness and typically occurs early in life, prevents the ontogenetic loss of the ASM hyperresponsive phenot...

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Bibliographic Details
Main Authors: Chitano, Pasquale, Wang, Lu, Degan, Simone, Worthington, Charles L., Pozzato, Valeria, Hussaini, Syed H., Turner, Wesley C., Dorscheid, Delbert R., Murphy, Thomas M.
Format: Online
Language:English
Published: Wiley Periodicals, Inc. 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4332219/