Structural and dynamic properties that govern the stability of an engineered fibronectin type III domain

Structural and dynamic properties that govern the stability of an engineered fibronectin type III domain

Consensus protein design is a rapid and reliable technique for the improvement of protein stability, which relies on the use of homologous protein sequences. To enhance the stability of a fibronectin type III (FN3) domain, consensus design was employed using an alignment of 2123 sequences. The resul...

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Bibliographic Details
Main Authors: Porebski, Benjamin T., Nickson, Adrian A., Hoke, David E., Hunter, Morag R., Zhu, Liguang, McGowan, Sheena, Webb, Geoffrey I., Buckle, Ashley M.
Format: Online
Language:English
Published: Oxford University Press 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4330816/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4330816/

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