Application of IL-36 receptor antagonist weakens CCL20 expression and impairs recovery in the late phase of murine acetaminophen-induced liver injury

Application of IL-36 receptor antagonist weakens CCL20 expression and impairs recovery in the late phase of murine acetaminophen-induced liver injury

Overdosing of the analgesic acetaminophen (APAP, paracetamol) is a major cause of acute liver injury. Whereas toxicity is initiated by hepatocyte necrosis, course of disease is regulated by mechanisms of innate immunity having the potential to serve in complex manner pathogenic or pro-regenerative f...

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Bibliographic Details
Main Authors: Scheiermann, Patrick, Bachmann, Malte, Härdle, Lorena, Pleli, Thomas, Piiper, Albrecht, Zwissler, Bernhard, Pfeilschifter, Josef, Mühl, Heiko
Format: Online
Language:English
Published: Nature Publishing Group 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4330543/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4330543/

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