Functional regulation of the DNA damage-recognition factor DDB2 by ubiquitination and interaction with xeroderma pigmentosum group C protein

Functional regulation of the DNA damage-recognition factor DDB2 by ubiquitination and interaction with xeroderma pigmentosum group C protein

In mammalian nucleotide excision repair, the DDB1–DDB2 complex recognizes UV-induced DNA photolesions and facilitates recruitment of the XPC complex. Upon binding to damaged DNA, the Cullin 4 ubiquitin ligase associated with DDB1–DDB2 is activated and ubiquitinates DDB2 and XPC. The structurally dis...

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Bibliographic Details
Main Authors: Matsumoto, Syota, Fischer, Eric S., Yasuda, Takeshi, Dohmae, Naoshi, Iwai, Shigenori, Mori, Toshio, Nishi, Ryotaro, Yoshino, Ken-ichi, Sakai, Wataru, Hanaoka, Fumio, Thomä, Nicolas H., Sugasawa, Kaoru
Format: Online
Language:English
Published: Oxford University Press 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4330392/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4330392/

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