The ABCG2 Polymorphism rs2725220 Is Associated with Hyperuricemia in the Korean Population

Elevated serum uric acid levels are associated with a variety of adverse health outcomes, including gout, hypertension, diabetes mellitus, metabolic syndrome, and cardiovascular diseases. Several genome-wide association studies on uric acid levels have implicated the ATP-binding cassette, subfamily...

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Main Authors:	Sull, Jae Woong, Yang, Seung-Ju, Kim, Soriul, Jee, Sun Ha
Format:	Online
Language:	English
Published:	Korea Genome Organization 2014
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4330259/

id	pubmed-4330259
recordtype	oai_dc
spelling	pubmed-43302592015-02-22 The ABCG2 Polymorphism rs2725220 Is Associated with Hyperuricemia in the Korean Population Sull, Jae Woong Yang, Seung-Ju Kim, Soriul Jee, Sun Ha Original Article Elevated serum uric acid levels are associated with a variety of adverse health outcomes, including gout, hypertension, diabetes mellitus, metabolic syndrome, and cardiovascular diseases. Several genome-wide association studies on uric acid levels have implicated the ATP-binding cassette, subfamily G, member 2 (ABCG2) gene as being possibly causal. We investigated an association between the single-nucleotide polymorphism (SNP) rs2725220 in the ABCG2 gene and uric acid levels in the Korean population. A total of 991 subjects in Seoul City were used for a replication study with ABCG2 SNP rs2725220. The rs2725220 SNP in the ABCG2 gene was associated with mean uric acid levels (effect per allele 0.25 mg/dL, p < 0.0001). Subjects with the GC/CC genotype had a 1.78-fold (range, 1.22- to 2.62-fold) higher risk of having abnormal uric acid levels (≥7.0 mg/dL) than subjects with the GG genotype. When analyzed by gender, the association with ABCG2 was stronger in men than in women. The association with ABCG2 was much stronger in male subjects with body mass index (BMI) ≥ 26.4 (odds ratio, 5.09; 95% confidence interval, 2.41 to 10.8) than in male subjects with BMI < 26.4. This study clearly demonstrates that genetic variations in ABCG2 influence uric acid levels in Korean adults. Korea Genome Organization 2014-12 2014-12-31 /pmc/articles/PMC4330259/ /pubmed/25705163 http://dx.doi.org/10.5808/GI.2014.12.4.231 Text en Copyright © 2014 by the Korea Genome Organization http://creativecommons.org/licenses/by-nc/3.0/ It is identical to the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/).
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Sull, Jae Woong Yang, Seung-Ju Kim, Soriul Jee, Sun Ha
spellingShingle	Sull, Jae Woong Yang, Seung-Ju Kim, Soriul Jee, Sun Ha The ABCG2 Polymorphism rs2725220 Is Associated with Hyperuricemia in the Korean Population
author_facet	Sull, Jae Woong Yang, Seung-Ju Kim, Soriul Jee, Sun Ha
author_sort	Sull, Jae Woong
title	The ABCG2 Polymorphism rs2725220 Is Associated with Hyperuricemia in the Korean Population
title_short	The ABCG2 Polymorphism rs2725220 Is Associated with Hyperuricemia in the Korean Population
title_full	The ABCG2 Polymorphism rs2725220 Is Associated with Hyperuricemia in the Korean Population
title_fullStr	The ABCG2 Polymorphism rs2725220 Is Associated with Hyperuricemia in the Korean Population
title_full_unstemmed	The ABCG2 Polymorphism rs2725220 Is Associated with Hyperuricemia in the Korean Population
title_sort	abcg2 polymorphism rs2725220 is associated with hyperuricemia in the korean population
description	Elevated serum uric acid levels are associated with a variety of adverse health outcomes, including gout, hypertension, diabetes mellitus, metabolic syndrome, and cardiovascular diseases. Several genome-wide association studies on uric acid levels have implicated the ATP-binding cassette, subfamily G, member 2 (ABCG2) gene as being possibly causal. We investigated an association between the single-nucleotide polymorphism (SNP) rs2725220 in the ABCG2 gene and uric acid levels in the Korean population. A total of 991 subjects in Seoul City were used for a replication study with ABCG2 SNP rs2725220. The rs2725220 SNP in the ABCG2 gene was associated with mean uric acid levels (effect per allele 0.25 mg/dL, p < 0.0001). Subjects with the GC/CC genotype had a 1.78-fold (range, 1.22- to 2.62-fold) higher risk of having abnormal uric acid levels (≥7.0 mg/dL) than subjects with the GG genotype. When analyzed by gender, the association with ABCG2 was stronger in men than in women. The association with ABCG2 was much stronger in male subjects with body mass index (BMI) ≥ 26.4 (odds ratio, 5.09; 95% confidence interval, 2.41 to 10.8) than in male subjects with BMI < 26.4. This study clearly demonstrates that genetic variations in ABCG2 influence uric acid levels in Korean adults.
publisher	Korea Genome Organization
publishDate	2014
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4330259/
_version_	1613188975073165312

The ABCG2 Polymorphism rs2725220 Is Associated with Hyperuricemia in the Korean Population

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