Double minute amplification of mutant PDGF receptor α in a mouse glioma model

Double minute amplification of mutant PDGF receptor α in a mouse glioma model

In primary brain tumors, oncogenes are frequently amplified and maintained on extrachromosomal DNA as double minutes (DM), but the underlying mechanisms remain poorly understood. We have generated a mouse model of malignant glioma based on knock-in of a mutant PDGF receptor α (PDGFRα) that is expres...

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Bibliographic Details
Main Authors: Zou, Hongyan, Feng, Rui, Huang, Yong, Tripodi, Joseph, Najfeld, Vesna, Tsankova, Nadejda M., Jahanshahi, Maryam, Olson, Lorin E., Soriano, Philippe, Friedel, Roland H.
Format: Online
Language:English
Published: Nature Publishing Group 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4329559/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4329559/

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