Nonirradiated NOD,B6.SCID Il2rγ−/−KitW41/W41 (NBSGW) Mice Support Multilineage Engraftment of Human Hematopoietic Cells

Nonirradiated NOD,B6.SCID Il2rγ−/−KitW41/W41 (NBSGW) Mice Support Multilineage Engraftment of Human Hematopoietic Cells

In this study, we demonstrate a newly derived mouse model that supports engraftment of human hematopoietic stem cells (HSCs) in the absence of irradiation. We cross the NOD.Cg-PrkdcscidIl2rgtm1Wjl/SzJ (NSG) strain with the C57BL/6J-KitW-41J/J (C57BL/6.KitW41) strain and engraft, without irradiation,...

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Bibliographic Details
Main Authors: McIntosh, Brian E., Brown, Matthew E., Duffin, Bret M., Maufort, John P., Vereide, David T., Slukvin, Igor I., Thomson, James A.
Format: Online
Language:English
Published: Elsevier 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4325197/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4325197/

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