Pharmacological modulation of the AKT/microRNA-199a-5p/CAV1 pathway ameliorates cystic fibrosis lung hyper-inflammation

Pharmacological modulation of the AKT/microRNA-199a-5p/CAV1 pathway ameliorates cystic fibrosis lung hyper-inflammation

In Cystic Fibrosis (CF) patients, hyper-inflammation is a key factor in lung destruction and disease morbidity. We have previously demonstrated that macrophages drive the lung hyper-inflammatory response to LPS in CF mice, due to reduced levels of the scaffold protein CAV1 with subsequent uncontroll...

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Bibliographic Details
Main Authors: Zhang, Ping-xia, Cheng, Jijun, Zou, Siying, D’Souza, Anthony D., Koff, Jonathan L., Lu, Jun, Lee, Patty J., Krause, Diane S., Egan, Marie E., Bruscia, Emanuela M.
Format: Online
Language:English
Published: 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4324503/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4324503/

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