Deficits in Endogenous Adenosine Formation by Ecto-5′-Nucleotidase/CD73 Impair Neuromuscular Transmission and Immune Competence in Experimental Autoimmune Myasthenia Gravis

Deficits in Endogenous Adenosine Formation by Ecto-5′-Nucleotidase/CD73 Impair Neuromuscular Transmission and Immune Competence in Experimental Autoimmune Myasthenia Gravis

AMP dephosphorylation via ecto-5′-nucleotidase/CD73 is the rate limiting step to generate extracellular adenosine (ADO) from released adenine nucleotides. ADO, via A2A receptors (A2ARs), is a potent modulator of neuromuscular and immunological responses. The pivotal role of ecto-5′-nucleotidase/CD73...

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Bibliographic Details
Main Authors: Oliveira, Laura, Correia, Alexandra, Cristina Costa, Ana, Guerra-Gomes, Sónia, Ferreirinha, Fátima, Magalhães-Cardoso, Maria Teresa, Vilanova, Manuel, Correia-de-Sá, Paulo
Format: Online
Language:English
Published: Hindawi Publishing Corporation 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4322825/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4322825/

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