A Novel TGFβ Modulator that Uncouples R-Smad/I-Smad-Mediated Negative Feedback from R-Smad/Ligand-Driven Positive Feedback

A Novel TGFβ Modulator that Uncouples R-Smad/I-Smad-Mediated Negative Feedback from R-Smad/Ligand-Driven Positive Feedback

As some of the most widely utilised intercellular signalling molecules, transforming growth factor β (TGFβ) superfamily members play critical roles in normal development and become disrupted in human disease. Establishing appropriate levels of TGFβ signalling involves positive and negative feedback,...

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Bibliographic Details
Main Authors: Gu, Wenchao, Monteiro, Rui, Zuo, Jie, Simões, Filipa Costa, Martella, Andrea, Andrieu-Soler, Charlotte, Grosveld, Frank, Sauka-Spengler, Tatjana, Patient, Roger
Format: Online
Language:English
Published: Public Library of Science 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4321984/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4321984/

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