Nanocomplexation of thrombin with cationic amylose derivative for improved stability and hemostatic efficacy

As a topical hemostatic agent, thrombin has wide application for many surgical treatments. However, native thrombin always suffers from its physical and chemical instabilities. In this work, a nanocomplexation strategy was developed for modifying the stability and hemostatic efficacy of thrombin, in...

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Bibliographic Details
Main Authors: Zhuang, Baoxiong, Li, Zhihua, Pang, Jiadong, Li, Wenbin, Huang, Pinbo, Wang, Jie, Zhou, Yu, Lin, Qing, Zhou, Quanbo, Ye, Xiao, Ye, Huilin, Liu, Yimin, Zhang, Li-Ming, Chen, Rufu
Format: Online
Language:English
Published: Dove Medical Press 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4321601/