Whole-genome sequencing to understand the genetic architecture of common gene expression and biomarker phenotypes

Whole-genome sequencing to understand the genetic architecture of common gene expression and biomarker phenotypes

Initial results from sequencing studies suggest that there are relatively few low-frequency (<5%) variants associated with large effects on common phenotypes. We performed low-pass whole-genome sequencing in 680 individuals from the InCHIANTI study to test two primary hypotheses: (i) that sequenc...

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Bibliographic Details
Main Authors: Wood, Andrew R., Tuke, Marcus A., Nalls, Mike, Hernandez, Dena, Gibbs, J. Raphael, Lin, Haoxiang, Xu, Christopher S., Li, Qibin, Shen, Juan, Jun, Goo, Almeida, Marcio, Tanaka, Toshiko, Perry, John R. B., Gaulton, Kyle, Rivas, Manny, Pearson, Richard, Curran, Joanne E., Johnson, Matthew P., Göring, Harald H. H., Duggirala, Ravindranath, Blangero, John, Mccarthy, Mark I., Bandinelli, Stefania, Murray, Anna, Weedon, Michael N., Singleton, Andrew, Melzer, David, Ferrucci, Luigi, Frayling, Timothy M
Format: Online
Language:English
Published: Oxford University Press 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4321449/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4321449/

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