Carbamoyl Radical-Mediated Synthesis and Semipinacol Rearrangement of β-Lactam Diols

In an approach to the biologically important 6-azabicyclo[3.2.1]octane ring system, the scope of the tandem 4-exo-trig carbamoyl radical cyclization—dithiocarbamate group transfer reaction to ring-fused β-lactams is evaluated. β-Lactams fused to five-, six-, and seven-membered rings are prepared in...

Full description

Bibliographic Details
Main Authors: Betou, Marie, Male, Louise, Steed, Jonathan W, Grainger, Richard S
Format: Online
Language:English
Published: WILEY-VCH Verlag 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4320754/