Anti-Human α-Synuclein N-Terminal Peptide Antibody Protects against Dopaminergic Cell Death and Ameliorates Behavioral Deficits in an AAV-α-Synuclein Rat Model of Parkinson’s Disease

Anti-Human α-Synuclein N-Terminal Peptide Antibody Protects against Dopaminergic Cell Death and Ameliorates Behavioral Deficits in an AAV-α-Synuclein Rat Model of Parkinson’s Disease

The protein α-synuclein (α-Syn) has a central role in the pathogenesis of Parkinson’s disease (PD) and immunotherapeutic approaches targeting this molecule have shown promising results. In this study, novel antibodies were generated against specific peptides from full length human α-Syn and evaluate...

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Bibliographic Details
Main Authors: Shahaduzzaman, Md, Nash, Kevin, Hudson, Charles, Sharif, Masroor, Grimmig, Bethany, Lin, Xiaoyang, Bai, Ge, Liu, Hui, Ugen, Kenneth E., Cao, Chuanhai, Bickford, Paula C.
Format: Online
Language:English
Published: Public Library of Science 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4319932/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4319932/

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