Control of repeat protein curvature by computational protein design

Shape complementarity is an important component of molecular recognition, and the ability to precisely adjust the shape of a binding scaffold to match a target of interest would greatly facilitate the creation of high affinity protein reagents and therapeutics. Here we describe a general approach to...

Full description

Bibliographic Details
Main Authors: Park, Keunwan, Shen, Betty W., Parmeggiani, Fabio, Huang, Po-Ssu, Stoddard, Barry L., Baker, David
Format: Online
Language:English
Published: 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4318719/