Context-dependent activation of Wnt signaling by tumor suppressor RUNX3 in gastric cancer cells
RUNX3 is a tumor suppressor for a variety of cancers. RUNX3 suppresses the canonical Wnt signaling pathway by binding to the TCF4/β-catenin complex, resulting in the inhibition of binding of the complex to the Wnt target gene promoter. Here, we confirmed that RUNX3 suppressed Wnt signaling activity...
| Main Authors: | , , , , , |
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| Format: | Online |
| Language: | English |
| Published: |
Blackwell Publishing Ltd
2014
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4317806/ |