A concise synthesis of Fingolimod: an orally available drug for treating multiple sclerosis
A concise route for the synthesis of Fingolimod is reported. Starting from n-octylbenzene and 3-nitropropionic acid, a sequence of reactions consisting of Friedel-Crafts acylation, reduction, and double Henry reaction, followed by hydrogenation were applied to prepare Fingolimod with a yield of 31%,...
Main Authors: | , , , , |
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Format: | Online |
Language: | English |
Published: |
Springer International Publishing
2015
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Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4317520/ |