A concise synthesis of Fingolimod: an orally available drug for treating multiple sclerosis
A concise route for the synthesis of Fingolimod is reported. Starting from n-octylbenzene and 3-nitropropionic acid, a sequence of reactions consisting of Friedel-Crafts acylation, reduction, and double Henry reaction, followed by hydrogenation were applied to prepare Fingolimod with a yield of 31%,...
| Main Authors: | , , , , |
|---|---|
| Format: | Online |
| Language: | English |
| Published: |
Springer International Publishing
2015
|
| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4317520/ |