UCHL1 provides diagnostic and antimetastatic strategies due to its deubiquitinating effect on HIF-1α

UCHL1 provides diagnostic and antimetastatic strategies due to its deubiquitinating effect on HIF-1α

Hypoxia-inducible factor 1 (HIF-1) plays a role in tumour metastases; however, the genes that activate HIF-1 and subsequently promote metastases have yet to be identified. Here we show that Ubiquitin C-terminal hydrolase-L1 (UCHL1) abrogates the von Hippel–Lindau-mediated ubiquitination of HIF-1α, t...

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Bibliographic Details
Main Authors: Goto, Yoko, Zeng, Lihua, Yeom, Chan Joo, Zhu, Yuxi, Morinibu, Akiyo, Shinomiya, Kazumi, Kobayashi, Minoru, Hirota, Kiichi, Itasaka, Satoshi, Yoshimura, Michio, Tanimoto, Keiji, Torii, Masae, Sowa, Terumasa, Menju, Toshi, Sonobe, Makoto, Kakeya, Hideaki, Toi, Masakazu, Date, Hiroshi, Hammond, Ester M., Hiraoka, Masahiro, Harada, Hiroshi
Format: Online
Language:English
Published: Nature Pub. Group 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4317501/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4317501/

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