Spatial and temporal distribution of visual information coding in lateral prefrontal cortex

Prefrontal neurons code many kinds of behaviourally relevant visual information. In behaving monkeys, we used a cued target detection task to address coding of objects, behavioural categories and spatial locations, examining the temporal evolution of neural activity across dorsal and ventral regions...

Full description

Bibliographic Details
Main Authors:	Kadohisa, Mikiko, Kusunoki, Makoto, Petrov, Philippe, Sigala, Natasha, Buckley, Mark J, Gaffan, David, Duncan, John
Format:	Online
Language:	English
Published:	Blackwell Publishing Ltd 2015
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4315869/

id	pubmed-4315869
recordtype	oai_dc
spelling	pubmed-43158692015-02-11 Spatial and temporal distribution of visual information coding in lateral prefrontal cortex Kadohisa, Mikiko Kusunoki, Makoto Petrov, Philippe Sigala, Natasha Buckley, Mark J Gaffan, David Duncan, John Behavioral Neuroscience Prefrontal neurons code many kinds of behaviourally relevant visual information. In behaving monkeys, we used a cued target detection task to address coding of objects, behavioural categories and spatial locations, examining the temporal evolution of neural activity across dorsal and ventral regions of the lateral prefrontal cortex (encompassing parts of areas 9, 46, 45A and 8A), and across the two cerebral hemispheres. Within each hemisphere there was little evidence for regional specialisation, with neurons in dorsal and ventral regions showing closely similar patterns of selectivity for objects, categories and locations. For a stimulus in either visual field, however, there was a strong and temporally specific difference in response in the two cerebral hemispheres. In the first part of the visual response (50–250 ms from stimulus onset), processing in each hemisphere was largely restricted to contralateral stimuli, with strong responses to such stimuli, and selectivity for both object and category. Later (300–500 ms), responses to ipsilateral stimuli also appeared, many cells now responding more strongly to ipsilateral than to contralateral stimuli, and many showing selectivity for category. Activity on error trials showed that late activity in both hemispheres reflected the animal's final decision. As information is processed towards a behavioural decision, its encoding spreads to encompass large, bilateral regions of prefrontal cortex. Blackwell Publishing Ltd 2015-01 2014-10-11 /pmc/articles/PMC4315869/ /pubmed/25307044 http://dx.doi.org/10.1111/ejn.12754 Text en © 2014 The Authors. European Journal of Neuroscience published by Federation of European Neuroscience Societies and John Wiley & Sons Ltd. http://creativecommons.org/licenses/by/4.0/ This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Kadohisa, Mikiko Kusunoki, Makoto Petrov, Philippe Sigala, Natasha Buckley, Mark J Gaffan, David Duncan, John
spellingShingle	Kadohisa, Mikiko Kusunoki, Makoto Petrov, Philippe Sigala, Natasha Buckley, Mark J Gaffan, David Duncan, John Spatial and temporal distribution of visual information coding in lateral prefrontal cortex
author_facet	Kadohisa, Mikiko Kusunoki, Makoto Petrov, Philippe Sigala, Natasha Buckley, Mark J Gaffan, David Duncan, John
author_sort	Kadohisa, Mikiko
title	Spatial and temporal distribution of visual information coding in lateral prefrontal cortex
title_short	Spatial and temporal distribution of visual information coding in lateral prefrontal cortex
title_full	Spatial and temporal distribution of visual information coding in lateral prefrontal cortex
title_fullStr	Spatial and temporal distribution of visual information coding in lateral prefrontal cortex
title_full_unstemmed	Spatial and temporal distribution of visual information coding in lateral prefrontal cortex
title_sort	spatial and temporal distribution of visual information coding in lateral prefrontal cortex
description	Prefrontal neurons code many kinds of behaviourally relevant visual information. In behaving monkeys, we used a cued target detection task to address coding of objects, behavioural categories and spatial locations, examining the temporal evolution of neural activity across dorsal and ventral regions of the lateral prefrontal cortex (encompassing parts of areas 9, 46, 45A and 8A), and across the two cerebral hemispheres. Within each hemisphere there was little evidence for regional specialisation, with neurons in dorsal and ventral regions showing closely similar patterns of selectivity for objects, categories and locations. For a stimulus in either visual field, however, there was a strong and temporally specific difference in response in the two cerebral hemispheres. In the first part of the visual response (50–250 ms from stimulus onset), processing in each hemisphere was largely restricted to contralateral stimuli, with strong responses to such stimuli, and selectivity for both object and category. Later (300–500 ms), responses to ipsilateral stimuli also appeared, many cells now responding more strongly to ipsilateral than to contralateral stimuli, and many showing selectivity for category. Activity on error trials showed that late activity in both hemispheres reflected the animal's final decision. As information is processed towards a behavioural decision, its encoding spreads to encompass large, bilateral regions of prefrontal cortex.
publisher	Blackwell Publishing Ltd
publishDate	2015
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4315869/
_version_	1613183888094396416

Spatial and temporal distribution of visual information coding in lateral prefrontal cortex

Similar Items