Developmental genetics of the Caenorhabditis elegans pharynx
The Caenorhabditis elegans pharynx is a rhythmically pumping organ composed initially of 80 cells that, through fusions, amount to 62 cells in the adult worm. During the first 100 min of development, most future pharyngeal cells are born and gather into a double-plate primordium surrounded by a basa...
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| Format: | Online |
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John Wiley & Sons, Inc.
2014
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4314705/ |
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pubmed-43147052015-02-04 Developmental genetics of the Caenorhabditis elegans pharynx Pilon, Marc Advanced Review The Caenorhabditis elegans pharynx is a rhythmically pumping organ composed initially of 80 cells that, through fusions, amount to 62 cells in the adult worm. During the first 100 min of development, most future pharyngeal cells are born and gather into a double-plate primordium surrounded by a basal lamina. All pharyngeal cells express the transcription factor PHA-4, of which the concentration increases throughout development, triggering a sequential activation of genes with promoters responding differentially to PHA-4 protein levels. The oblong-shaped pharyngeal primordium becomes polarized, many cells taking on wedge shapes with their narrow ends toward the center, hence forming an epithelial cyst. The primordium then elongates, and reorientations of the cells at the anterior and posterior ends form the mouth and pharyngeal-intestinal openings, respectively. The 20 pharyngeal neurons establish complex but reproducible trajectories using ‘fishing line’ and growth cone-driven mechanisms, and the gland cells also similarly develop their processes. The genetics behind many fate decisions and morphogenetic processes are being elucidated, and reveal the pharynx to be a fruitful model for developmental biologists. John Wiley & Sons, Inc. 2014-07 2014-05-23 /pmc/articles/PMC4314705/ /pubmed/25262818 http://dx.doi.org/10.1002/wdev.139 Text en © 2014 The Authors. WIREs Developmental Biology published by Wiley Periodicals, Inc. http://creativecommons.org/licenses/by-nc/3.0/ This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Pilon, Marc |
| spellingShingle |
Pilon, Marc Developmental genetics of the Caenorhabditis elegans pharynx |
| author_facet |
Pilon, Marc |
| author_sort |
Pilon, Marc |
| title |
Developmental genetics of the Caenorhabditis elegans pharynx |
| title_short |
Developmental genetics of the Caenorhabditis elegans pharynx |
| title_full |
Developmental genetics of the Caenorhabditis elegans pharynx |
| title_fullStr |
Developmental genetics of the Caenorhabditis elegans pharynx |
| title_full_unstemmed |
Developmental genetics of the Caenorhabditis elegans pharynx |
| title_sort |
developmental genetics of the caenorhabditis elegans pharynx |
| description |
The Caenorhabditis elegans pharynx is a rhythmically pumping organ composed initially of 80 cells that, through fusions, amount to 62 cells in the adult worm. During the first 100 min of development, most future pharyngeal cells are born and gather into a double-plate primordium surrounded by a basal lamina. All pharyngeal cells express the transcription factor PHA-4, of which the concentration increases throughout development, triggering a sequential activation of genes with promoters responding differentially to PHA-4 protein levels. The oblong-shaped pharyngeal primordium becomes polarized, many cells taking on wedge shapes with their narrow ends toward the center, hence forming an epithelial cyst. The primordium then elongates, and reorientations of the cells at the anterior and posterior ends form the mouth and pharyngeal-intestinal openings, respectively. The 20 pharyngeal neurons establish complex but reproducible trajectories using ‘fishing line’ and growth cone-driven mechanisms, and the gland cells also similarly develop their processes. The genetics behind many fate decisions and morphogenetic processes are being elucidated, and reveal the pharynx to be a fruitful model for developmental biologists. |
| publisher |
John Wiley & Sons, Inc. |
| publishDate |
2014 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4314705/ |
| _version_ |
1613183452614492160 |