Moderate Exercise Training Attenuates the Severity of Experimental Rodent Colitis: The Importance of Crosstalk between Adipose Tissue and Skeletal Muscles

Although progress has been recently made in understanding of inflammatory bowel diseases (IBD), their etiology is unknown apart from several factors from adipose tissue and skeletal muscles such as cytokines, adipokines, and myokines were implicated in the pathogenesis of ulcerative colitis. We stud...

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Main Authors:	Bilski, Jan, Mazur-Bialy, Agnieszka I., Brzozowski, Bartosz, Magierowski, Marcin, Jasnos, Katarzyna, Krzysiek-Maczka, Gracjana, Urbanczyk, Katarzyna, Ptak-Belowska, Agata, Zwolinska-Wcislo, Malgorzata, Mach, Tomasz, Brzozowski, Tomasz
Format:	Online
Language:	English
Published:	Hindawi Publishing Corporation 2015
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4313673/

id	pubmed-4313673
recordtype	oai_dc
spelling	pubmed-43136732015-02-15 Moderate Exercise Training Attenuates the Severity of Experimental Rodent Colitis: The Importance of Crosstalk between Adipose Tissue and Skeletal Muscles Bilski, Jan Mazur-Bialy, Agnieszka I. Brzozowski, Bartosz Magierowski, Marcin Jasnos, Katarzyna Krzysiek-Maczka, Gracjana Urbanczyk, Katarzyna Ptak-Belowska, Agata Zwolinska-Wcislo, Malgorzata Mach, Tomasz Brzozowski, Tomasz Research Article Although progress has been recently made in understanding of inflammatory bowel diseases (IBD), their etiology is unknown apart from several factors from adipose tissue and skeletal muscles such as cytokines, adipokines, and myokines were implicated in the pathogenesis of ulcerative colitis. We studied the effect high-fat diet (HFD; cholesterol up to 70%), low-fat diet (LFD; cholesterol up to 10%), and the normal diet (total fat up to 5%) in rats with TNBS colitis forced to treadmill running exercise (5 days/week) for 6 weeks. In nonexercising HFD rats, the area of colonic damage, colonic tissue weight, the plasma IL-1β, TNF-α, TWEAK, and leptin levels, and the expression of IL-1β-, TNF-α-, and Hif1α mRNAs were significantly increased and a significant fall in plasma adiponectin and irisin levels was observed as compared to LFD rats. In HFD animals, the exercise significantly accelerated the healing of colitis, raised the plasma levels of IL-6 and irisin, downregulated the expression of IL-1β, TNF-α, and Hif1α, and significantly decreased the plasma IL-1β, TNF α, TWEAK, and leptin levels. We conclude that HFD delays the healing of colitis in trained rats via decrease in CBF and plasma IL-1β, TNF-α, TWEAK, and leptin levels and the release of protective irisin. Hindawi Publishing Corporation 2015 2015-01-05 /pmc/articles/PMC4313673/ /pubmed/25684862 http://dx.doi.org/10.1155/2015/605071 Text en Copyright © 2015 Jan Bilski et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Bilski, Jan Mazur-Bialy, Agnieszka I. Brzozowski, Bartosz Magierowski, Marcin Jasnos, Katarzyna Krzysiek-Maczka, Gracjana Urbanczyk, Katarzyna Ptak-Belowska, Agata Zwolinska-Wcislo, Malgorzata Mach, Tomasz Brzozowski, Tomasz
spellingShingle	Bilski, Jan Mazur-Bialy, Agnieszka I. Brzozowski, Bartosz Magierowski, Marcin Jasnos, Katarzyna Krzysiek-Maczka, Gracjana Urbanczyk, Katarzyna Ptak-Belowska, Agata Zwolinska-Wcislo, Malgorzata Mach, Tomasz Brzozowski, Tomasz Moderate Exercise Training Attenuates the Severity of Experimental Rodent Colitis: The Importance of Crosstalk between Adipose Tissue and Skeletal Muscles
author_facet	Bilski, Jan Mazur-Bialy, Agnieszka I. Brzozowski, Bartosz Magierowski, Marcin Jasnos, Katarzyna Krzysiek-Maczka, Gracjana Urbanczyk, Katarzyna Ptak-Belowska, Agata Zwolinska-Wcislo, Malgorzata Mach, Tomasz Brzozowski, Tomasz
author_sort	Bilski, Jan
title	Moderate Exercise Training Attenuates the Severity of Experimental Rodent Colitis: The Importance of Crosstalk between Adipose Tissue and Skeletal Muscles
title_short	Moderate Exercise Training Attenuates the Severity of Experimental Rodent Colitis: The Importance of Crosstalk between Adipose Tissue and Skeletal Muscles
title_full	Moderate Exercise Training Attenuates the Severity of Experimental Rodent Colitis: The Importance of Crosstalk between Adipose Tissue and Skeletal Muscles
title_fullStr	Moderate Exercise Training Attenuates the Severity of Experimental Rodent Colitis: The Importance of Crosstalk between Adipose Tissue and Skeletal Muscles
title_full_unstemmed	Moderate Exercise Training Attenuates the Severity of Experimental Rodent Colitis: The Importance of Crosstalk between Adipose Tissue and Skeletal Muscles
title_sort	moderate exercise training attenuates the severity of experimental rodent colitis: the importance of crosstalk between adipose tissue and skeletal muscles
description	Although progress has been recently made in understanding of inflammatory bowel diseases (IBD), their etiology is unknown apart from several factors from adipose tissue and skeletal muscles such as cytokines, adipokines, and myokines were implicated in the pathogenesis of ulcerative colitis. We studied the effect high-fat diet (HFD; cholesterol up to 70%), low-fat diet (LFD; cholesterol up to 10%), and the normal diet (total fat up to 5%) in rats with TNBS colitis forced to treadmill running exercise (5 days/week) for 6 weeks. In nonexercising HFD rats, the area of colonic damage, colonic tissue weight, the plasma IL-1β, TNF-α, TWEAK, and leptin levels, and the expression of IL-1β-, TNF-α-, and Hif1α mRNAs were significantly increased and a significant fall in plasma adiponectin and irisin levels was observed as compared to LFD rats. In HFD animals, the exercise significantly accelerated the healing of colitis, raised the plasma levels of IL-6 and irisin, downregulated the expression of IL-1β, TNF-α, and Hif1α, and significantly decreased the plasma IL-1β, TNF α, TWEAK, and leptin levels. We conclude that HFD delays the healing of colitis in trained rats via decrease in CBF and plasma IL-1β, TNF-α, TWEAK, and leptin levels and the release of protective irisin.
publisher	Hindawi Publishing Corporation
publishDate	2015
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4313673/
_version_	1613183153468342272

Moderate Exercise Training Attenuates the Severity of Experimental Rodent Colitis: The Importance of Crosstalk between Adipose Tissue and Skeletal Muscles

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