Basolateral amygdala regulation of adult hippocampal neurogenesis and fear-related activation of newborn neurons

Impaired regulation of emotional memory is a feature of several affective disorders, including depression, anxiety and post-traumatic stress disorder. Such regulation occurs, in part, by interactions between the hippocampus and the basolateral amygdala (BLA). Recent studies have indicated that withi...

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Main Authors:	Kirby, Elizabeth D., Friedman, Aaron R., Covarrubias, David, Ying, Carl, Sun, Wayne G., Goosens, Ki A., Sapolsky, Robert M., Kaufer, Daniela
Format:	Online
Language:	English
Published:	2011
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4310700/

id	pubmed-4310700
recordtype	oai_dc
spelling	pubmed-43107002015-01-29 Basolateral amygdala regulation of adult hippocampal neurogenesis and fear-related activation of newborn neurons Kirby, Elizabeth D. Friedman, Aaron R. Covarrubias, David Ying, Carl Sun, Wayne G. Goosens, Ki A. Sapolsky, Robert M. Kaufer, Daniela Article Impaired regulation of emotional memory is a feature of several affective disorders, including depression, anxiety and post-traumatic stress disorder. Such regulation occurs, in part, by interactions between the hippocampus and the basolateral amygdala (BLA). Recent studies have indicated that within the adult hippocampus, newborn neurons may contribute to support of emotional memory, and that regulation of hippocampal neurogenesis is implicated in depressive disorders. How emotional information impacts newborn neurons in adults is not clear. Given the role of the BLA in hippocampus-dependent emotional memory, we investigated whether hippocampal neurogenesis was sensitive to emotional stimuli from the BLA. We show that BLA lesions suppress adult neurogenesis, while lesions of the central nucleus of the amygdala do not. Similarly, we show that reducing BLA activity through viral vector-mediated overexpression of an outwardly rectifying potassium channel suppresses neurogenesis. We also show that BLA lesions prevent selective activation of immature newborn neurons in response to a fear conditioning task. These results demonstrate that BLA activity regulates adult hippocampal neurogenesis and the fear context-specific activation of newborn neurons. Together, these findings denote functional implications for proliferation and recruitment of new neurons into emotional memory circuits. 2011-06-14 2012-05 /pmc/articles/PMC4310700/ /pubmed/21670733 http://dx.doi.org/10.1038/mp.2011.71 Text en http://www.nature.com/authors/editorial_policies/license.html#terms Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Kirby, Elizabeth D. Friedman, Aaron R. Covarrubias, David Ying, Carl Sun, Wayne G. Goosens, Ki A. Sapolsky, Robert M. Kaufer, Daniela
spellingShingle	Kirby, Elizabeth D. Friedman, Aaron R. Covarrubias, David Ying, Carl Sun, Wayne G. Goosens, Ki A. Sapolsky, Robert M. Kaufer, Daniela Basolateral amygdala regulation of adult hippocampal neurogenesis and fear-related activation of newborn neurons
author_facet	Kirby, Elizabeth D. Friedman, Aaron R. Covarrubias, David Ying, Carl Sun, Wayne G. Goosens, Ki A. Sapolsky, Robert M. Kaufer, Daniela
author_sort	Kirby, Elizabeth D.
title	Basolateral amygdala regulation of adult hippocampal neurogenesis and fear-related activation of newborn neurons
title_short	Basolateral amygdala regulation of adult hippocampal neurogenesis and fear-related activation of newborn neurons
title_full	Basolateral amygdala regulation of adult hippocampal neurogenesis and fear-related activation of newborn neurons
title_fullStr	Basolateral amygdala regulation of adult hippocampal neurogenesis and fear-related activation of newborn neurons
title_full_unstemmed	Basolateral amygdala regulation of adult hippocampal neurogenesis and fear-related activation of newborn neurons
title_sort	basolateral amygdala regulation of adult hippocampal neurogenesis and fear-related activation of newborn neurons
description	Impaired regulation of emotional memory is a feature of several affective disorders, including depression, anxiety and post-traumatic stress disorder. Such regulation occurs, in part, by interactions between the hippocampus and the basolateral amygdala (BLA). Recent studies have indicated that within the adult hippocampus, newborn neurons may contribute to support of emotional memory, and that regulation of hippocampal neurogenesis is implicated in depressive disorders. How emotional information impacts newborn neurons in adults is not clear. Given the role of the BLA in hippocampus-dependent emotional memory, we investigated whether hippocampal neurogenesis was sensitive to emotional stimuli from the BLA. We show that BLA lesions suppress adult neurogenesis, while lesions of the central nucleus of the amygdala do not. Similarly, we show that reducing BLA activity through viral vector-mediated overexpression of an outwardly rectifying potassium channel suppresses neurogenesis. We also show that BLA lesions prevent selective activation of immature newborn neurons in response to a fear conditioning task. These results demonstrate that BLA activity regulates adult hippocampal neurogenesis and the fear context-specific activation of newborn neurons. Together, these findings denote functional implications for proliferation and recruitment of new neurons into emotional memory circuits.
publishDate	2011
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4310700/
_version_	1613182172221407232

Basolateral amygdala regulation of adult hippocampal neurogenesis and fear-related activation of newborn neurons

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